[Download] "Management of Maternal Amanita Phalloides Poisoning During the First Trimester of Pregnancy: A Case Report and Review of the Literature (Case Report)" by Clinical Chemistry " Book PDF Kindle ePub Free
eBook details
- Title: Management of Maternal Amanita Phalloides Poisoning During the First Trimester of Pregnancy: A Case Report and Review of the Literature (Case Report)
- Author : Clinical Chemistry
- Release Date : January 01, 2001
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 202 KB
Description
The diagnosis of suspected poisoning by Amanita phalloides remains a challenge to emergency physicians. This mushroom intoxication starts as gastroenteritis, progressing to liver failure and death as a result of hepatic coma. The mature A. phalloides, despite its distinctive green cap and white gills, can be mistaken, even by mycologists, for similar-appearing edible mushrooms (1). Unfortunately, these mushrooms have no unique smell or taste characteristics, and cooking does not destroy the two types of cyclic oligopeptide toxins, the amatoxin and the phallotoxins. Phalloidin, which constitutes the main agent of phallotoxins, is a cyclic thermostable and easily dialyzable octapeptide, with a molecular mass of ~900 Da (2). The sulfur atom of this compound, which is engaged in a thioamide bond with the indole ring, is responsible for a weak part of the toxicity of Amanita (e.g., only the initial symptoms of gastroenteritis). After formation of this latter bond, the polymerization of G-actin to F-actin is interrupted, leading to disorganization of the cytoskeleton and cell death.
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